A bike race injures several pedestrians as well as well as participants. One pedestrian is left brain dead. Christina and Issie wish to use his organs for organ donation but with Christinas detachment and Issies ever hopeful attitude that the man will recover, they will find the organ harvesting process an emotional one. Preston faces feelings of his dislike of organ harvesting - as a surgeon, he likes saving lives; harvesting organs doesnt save the persons life. George deals with Mac, a friend of the chief, who wont stop flirting with him. He is in need of a new liver. Meredith is fed up with Alex showing off as she continues trying to push Derek away. She also is reaching the limits of Issies sunshine and Georges politeness as she goes on living with them. Then there is their desire to see Merediths mothers medical tapes. Getting through the day, Meredith realizes the keys to winning the race.