Izzie tries to get George to find the courage to ask Meredith out. All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the womans prognosis is not good. Now that Bailey knows about Meredith and Dereks affair, their jobs are in jeopardy, and she advises Meredith to end it. Meanwhile, Cristina and Burkes secret relationship is also getting more complicated...